This present study investigates the role and mechanism of ECH in the pathological process of AD. However, the effects of ECH in Alzheimer's disease (AD) are not very clear. Therefore, we suggest that ECH may considered as a potential drug for AD treatment.Įchinacoside Improves Cognitive Impairment by Inhibiting Aβ Deposition Through the PI3K/AKT/Nrf2/PPARγ Signaling Pathways in APP/PS1 MiceĠ Department of Gynaecology and Obstetrics, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning, ChinaĮchinacoside (ECH), a phenylethanoid glycoside, has protective activity in neurodegenerative disease, including anti-inflammation and antioxidation. In conclusion, this paper reported that ECH improved cognitive function, inhibited oxidative stress, and inflammatory response in AD. Moreover, ECH inhibited glia cells activation, pro-inflammatory cytokine IL-1β and TNF-α release, NLRP3 inflammasome formation through TXNIP/Trx-1 signaling pathway. Furthermore, ECH decreased ROS formation, GP91 and 8-OHdG expression, upregulated the expression of SOD1 and SOD2 as well as activating the PI3K/AKT/Nrf2 signaling pathway. In addition, ECH significantly reduced the deposition of senile plaques in the brain and decreased the expression of BACE1 in APP/PS1 mice through activating PI3K/AKT/Nrf2/PPARγ pathway. The results showed that ECH alleviated the memory impairment of APP/PS1 mice by reducing the time of escape latency as well as increasing the times of crossing the platform and rescued the impaired ability to construct nests. Western blot used to study the mechanism of ECH improving AD pathology. Morris water maze, nesting test, and immunofluorescence staining used to observe whether ECH could improve AD pathology. APP/PS1 mice treated with ECH in 50 mg/kg/day for 3 months. However, the effects of ECH in Alzheimer’s disease (AD) are not very clear. Anti-Oxidant and Anti-Inflammatory Activity of Ketogenic Diet: New Perspectives for Neuroprotection in Alzheimer's Disease.Įchinacoside (ECH), a phenylethanoid glycoside, has protective activity in neurodegenerative disease, including anti-inflammation and antioxidation. Keap1 expression has independent prognostic value in pancreatic adenocarcinomas Keap1 expression has independent prognostic value in pancreatic adenocarcinomasĪnti-Oxidant and Anti-Inflammatory Activity of Ketogenic Diet: New. Nrf2 signaling and autophagy are complementary in protecting lipopolysaccharide/d-galactosamine-induced acute liver injury by licochalcone A Nrf2 signaling and autophagy are complementary in protecting. The Injury and Therapy of Reactive Oxygen Species in Intracerebral Hemorrhage Looking at Mitochondria The Injury and Therapy of Reactive Oxygen Species in Intracerebral Hemorrhage. The Atypical Antipsychotic Paliperidone Regulates Endogenous Antioxidant/Anti-Inflammatory Pathways in Rat Models of Acute and Chronic Restraint Stress The Atypical Antipsychotic Paliperidone Regulates Endogenous Antioxidant/Anti.
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